Background: A 6-year-old girl was diagnosed with childhood absence epilepsy (CAE) based on clinical history and video-recorded electroencephalogram (EEG). She was started on ethosuximide (ES; 150 mg twice daily), with a gradual increase over two weeks to a target dose of 250 mg twice daily. Case Report: The patient maintained a daily ES dose of 300 mg, supplementing it with gamma-aminobutyric acid (GABA; 3000 mg) and phosphatidylserine (PS; 200 mg from a liquid fish oil product). A follow-up EEG, done 23 months later, showed normal results. During nearly two years of integrative treatment, the patient experienced no seizures despite growth in height and weight. The integrative approach also improved her focus, reduced shyness, and promoted social engagement. Conclusion: This integrative approach, combining GABA and PS with ES, may have enhanced treatment effectiveness, maintained a low ES dose, and possibly minimized pharmaco-resistance. These positive outcomes suggest that a similar approach may benefit other patients with newly diagnosed CAE.