Background: Clinical conditions such as burnout, attention-deficit hyperactivity disorder (ADHD), and osteoarthritis (OA) have the potential to greatly impact an individual's daily functioning and overall quality of life. Case Report: A 52-year-old Caucasian female diagnosed with these conditions experienced significant physical and mental health improvements upon discontinuing aspartame-containing chewing gum. Despite various treatments and natural health products, her symptoms persisted until she stopped consuming aspartame. The patient's joint pain, mood, memory, and energy levels dramatically improved within 36 hours of ceasing aspartame intake. Conclusion: The report highlights the potential negative effects of aspartame on neuropsychiatric and somatic health, emphasizing the importance of considering dietary factors in therapeutic plans for complex clinical presentations. Further research is needed to explore the relationship between dietary additives like aspartame and medical conditions like burnout, ADHD, and OA.