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Journal of Case Reports
Effect of Cellular Therapy seen on Musculoskeletal Magnetic Resonance Imaging in a Case of Becker’s Muscular Dystrophy

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Alok Sharma1, Hemangi Sane2, Amruta Paranjape2, Prerna Badhe1, Nandini Gokulchandran1, Verghese Jacob3
From the Department of Medical Services and Clinical Research1, Department of Research and Development2, Department of Neuro-rehabilitation3; NeuroGen Brain and Spine Institute, Chembur, Mumbai-400071, Maharashtra, India.
Corresponding Author:
Amruta Paranjape
Email: publications@neurogen.in
Received: 18-OCT-2013 Accepted: 28-NOV-2013 Published Online: 05-DEC-2013
DOI: http://dx.doi.org/10.17659/01.2013.0101
Abstract
Becker’s Muscular dystrophy (BMD) is a disorder with a progressive course of muscle weakness leading to disability and premature death. Pharmacological and rehabilitative management is supportive and does not halt the progression of the disease. Novel treatment options of gene therapy and stem cell therapy may provide a promising solution by altering the basic pathology of the disease. Pre-clinical studies have shown safety and beneficial effects of bone marrow derived mononuclear cells transplantation in BMD.

In this case report, we treated a patient of BMD with a new multidisciplinary approach of Autologous Bone Marrow Mono Nuclear Cells (BMMNCs) followed by rigorous rehabilitation. The BMMNCs were transplanted via the intrathecal and intramuscular routes. The effects were measured in terms of clinical, functional and radiological changes. At 6 months after therapy the comparative Musculoskeletal Magnetic Resonance Imaging (MRI–MSK) showed regeneration of muscle fibers. This observation is one of the initial evidential data for muscle regeneration, in BMD patient, following cellular therapy. Although an observation only in a single case, it may support undertaking further research. Large clinical trials are required, with more robust methodology.  MRI-MSK may also be evaluated for monitoring the effects of cellular therapy.
Keywords : Muscular Dystrophy, Magnetic Resonance Imaging, Muscle Weakness, Bone marrow, Adult Stem Cells, Genetic Therapy.
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