We present the first reported case of Delftia acidovorans skin infection, occurring in a diabetic patient with significant peripheral oedema. D. acidovorans is a strictly aerobic, motile, Gram negative bacillus with similar rRNA genotype and microbiological phenotype as Pseudomonas. From a clinical perspective, this microorganism presents with similar risk factors, clinical manifestations and treatment options as those of Pseudomonal infections. Importantly, there is a high prevalence of aminoglycoside resistance. With increasing rates of iatrogenic immunosuppression, as well as increasing use of invasive devices, this normally low-virulence, environmental microorganism may become increasingly prevalent as an opportunistic pathogen in both immunocompromised and immunocompetent patients.