Kikuchi Fujimoto’s disease presents as enlarged tender lymphadenopathy accompanied by fever in Asian women in the fourth decade. Fine needle aspiration usually results in a necrotic aspirate, with absence of epithelioid cells or atypical cells. This prompts the clinician to advice for a whole node biopsy. Histopathology is characteristic with the presence of abundant karyorrhectic debris in a necrotic centre with presence of crescentic macrophages and lymphocytes in the margin. However, immunohistochemistry should be undertaken to rule out possibility of infections and lymphomas. We discuss an interesting case of a lady who presented with persistent cervical lymphadenopathy and fever with negative serum markers of lupus. A whole node biopsy with the compliment of immunohistochemistry helped to arrive at the diagnosis of Kikuchi- Fujimoto’s disease.